This is for theoretical argument only
1) A Complete Guide to Cocaine Synthesis.
2) Preparation of Freebase and "Crack"
3) Complete Guide to PCP Synthesis
COMMON & BRAND NAMES
Coke; Crack; Blow; Snow; Nose Candy
EFFECTS CLASSIFICATION
Euphoric Stimulant
CHEMICAL NAME
benzoylmethyl ecgonine
DESCRIPTION
Cocaine is a common stimulant derived from the Erythroxylum coca plant. It is best known for its massive popularity in powdered and freebase (crack) forms.
Cocaine Chemistry
NAME : Cocaine
CHEMICAL NAME : [1R-(exo,exo)]-3-(Benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid methyl ester
ALTERNATE CHEMICAL NAMES : 3beta-hydroxy-1alphaH, 5alphaH-tropane-2beta-carboxylic acid methyl ester benzoate
ALTERNATE CHEMICAL NAMES : 2beta-carbomethyoxy-3beta-benzoxytropane, ecgonine methyl ester benzoate
ALTERNATE CHEMICAL NAMES : l-cocaine, beta-cocaine, benzoylmethyl-ecgonine
CHEMICAL FORMULA C17H21NO4
MOLECULAR WEIGHT 303.36
MELTING POINT 98° (monoclinic tablets)
MELTING POINT 195° (Hydrochloride)
MELTING POINT 58-63° (Nitrate dihydrate)
Cocaine Synthesis
A Complete Guide to Manufacturing_ COCAINE Although this drug is categorized as a local anesthetic, I have chosen to put it in with the hallucinogens because of the psycho- tomimetic effects that it produces. Cocaine is not a phenylethyl- amine, but it produces central nervous system arousal or stimulant effects which closely resemble those of the amphetamines, the methylenedioxyamphetamines in particular. This is due to the inhibition by cocaine of re-uptake of the norepinepherine released by the adrenergic nerve terminals, leading to an enhanced adrenergic stimulation of norepinephrine receptors. The increased sense of well being and intense, but short lived, euphoric state produced by cocaine requires frequent administration. Cocaine does not penetrate the intact skin, but is readily absorbed from the mucus membranes, creating the need to snort it. This accounts for the ulceration of the nasal septum after cocaine has been snorted for long periods. The basic formula for cocaine starts by purchasing or making tropinone, converting the tropinone into 2-carbomethoxytropinone (also known as methyl-tropan-3-one-2-carboxylate), reducing this to ecgonine, and changing that to cocaine. Sounds easy? It really is not very simple, but with Reagan's new drug policies, cracking down on all of the drug smuggling at the borders, this synthetic cocaine may be the source of the future. This synthesis is certainly worth performing with the high prices that cocaine is now commanding. As usual, I will start with the precursors and intermediates leading up to the product. Succindialdehyde. This can be purchased, too. 23.2 g of succinaldoxime powder in 410 ml of 1 N sulfuric acid and add dropwise with stirring at 0¡ a solution of 27.6 g of sodium nitrite in 250 ml of water over 3 hours. After the addition, stir and let the mixture rise to room temp for about 2 hours, taking care not to let outside air into the reaction. Stir in 5 g of Ba carbonate and filter. Extract the filtrate with ether and dry, evaporate in vacuo to get the succindialdehyde. This was taken from JOC, 22, 1390 (1957). To make succinaldoxime, see JOC, 21, 644 (1956). Complete Synthesis of Succindialdehyde. JACS, 68, 1608 (1946). In a 2 liter 3 necked flask equipped with a stirrer, reflux condenser, and an addition funnel, is mixed 1 liter of ethanol, 67 g of freshly distilled pyrrole, and 141 g of hydroxylamine hydrochloride. Heat to reflux until dissolved, add 106 g of anhydrous sodium carbonate in small portions as fast as reaction will allow. Reflux for 24 hours and filter the mixture. Evaporate the filtrate to dryness under vacuo. Take up the residue in the minimum amount of boiling water, decolorize with carbon, filter and allow to recrystallize in refrigerator. Filter to get product and concentrate to get additional crop. Yield of succinaldoxime powder is a little over 40 g, mp is 171-172¡. 5.8 g of the above powder is placed in a beaker of 250 ml capacity and 54 ml of 10% sulfuric acid is added. Cool to 0¡ and add in small portions of 7 g of sodium nitrite (if you add the nitrite too fast, nitrogen dioxide fumes will evolve). After the dioxime is completely dissolved, allow the solution to warm to 20¡ and effervescence to go to completion. Neutralize the yellow solution to litmus by adding small portions of barium carbonate. Filter off the barium sulfate that precipitates. The filtrate is 90% pure succindialdehyde and is not purified further for the reaction to create tropinone. Do this procedure 3 more times to get the proper amount for the next step, or multiply the amounts given by four and proceed as described above. Take the total amount of succinaldehyde (obtained from 4 of the above syntheses combined) and without further treatment or purification (this had better be 15.5 g of succindialdehyde) put into an Erlenmeyer flask of 4-5 liters capacity. Add 21.6 g of methylamine hydrochloride, 46.7 g of acetonedicarboxylic acid, and enough water to make a total volume of 2 liters. Adjust the pH to 8-10 by slowly adding a saturated solution of disodium phosphate. The condensate of this reaction (allow to set for about 6 days) is extracted with ether, the ethereal solution is dried over sodium sulphate and distilled, the product coming over at 113¡ at 25 mm of pressure is collected. Upon cooling, 14 g of tropinone crystallizes in the pure state. Tropinone can also be obtained by oxidation of tropine with potassium dichromate, but I could not find the specifics for this operation. 2-Carbomethoxytropinone. A mixture of 1.35 g of sodium methoxide (this is sodium in a minimum amount of methanol), 3.5 g of tropinone, 4 ml of dimethylcarbonate and 10 ml of toluene is refluxed for 30 min. Coo] to 0¡ and add 15 ml of water that contains 2.5 g of ammonium chloride. Extract the solution after shaking with four 50 ml portions of chloroform, dry, evaporate the chloroform in vacuo. Dissolve the oil residue in 100 ml of ether, wash twice with a mixture of 6 ml of saturated potassium carbonate and three ml of 3 N KOH. Dry and evaporate in vacuo to recover the unreacted tropinone. Take up the oil in a solution of aqueous ammonium chloride and extract with chloroform, dry, and evaporate in vacuo to get an oil. The oil is dissolved in hot acetone, cool, and scratch inside of flask with glass rod to precipitate 2- carbomethoxytropinone. Recrystallize 16 g of this product in 30 ml of hot methyl acetate and add 4 ml of cold water and 4 ml of acetone. Put in freezer for 2l/2 to 3 hours. Filter and wash the precipitate with cold methyl acetate to get pure product. Methylecgonine. 0.4 mole of tropinone is suspended in 80 ml of ethanol in a Parr hydrogenation flask (or something that can take 100 psi and not react with the reaction, like stainless steel or glass). 10 g of Raney Nickle is added with good agitation (stirring or shaking) followed by 2- 3 ml of 20% NaOH solution. Seal vessel, introduce 50 psi of hydrogen atmosphere (after flushing vessel with hydrogen) and heat to 40-50¡. After no more uptake of hydrogen (pressure gauge will hold steady after dropping to its lowest point) bleed off pressure and filter the nickle off, rinse out bottle with chloroform and use this rinse to rinse off the nickle while still on the filter paper. Make the filtrate basic with KOH after cooling to 10¡. Extract with chloroform dry, and evaporate the chloroform in vacuo to get an oil. Mix the oil plus any precipitate with an equal volume of dry ether and filter. Add more dry ether to the filtrate until no more precipitate forms, filter and add to the rest of the precipitate. Recrystallize from isopropanol to get pure methylecgonine. Test for activity. If active, skip down to the step for cocaine. If not active, proceed as follows. Stir with activated carbon for 30 min, filter, evaporate in vacuo, dissolve the brown liquid in methanol, and neutralize with 10% HCI acid in dry ether. Evaporate the ether until the two layers disappear, and allow to stand for 2 hours at 0¡ to precipitate the title product. There are many ways to reduce 2-carbomethoxytropinone to methylecgonine. I chose to design a Raney Nickle reduction because it is cheap and not as suspicious as LAH and it is much easier than zinc or sodium amalgams. Cocaine. 4.15 g of methylecgonine and 5.7 g of benzoic anhydride in 150 ml of dry benzene are gently refluxed for 4 hours taking precaution against H20 in the air (drying tube). Cool in an ice bath, acidify carefully with hydrochloric acid, dry, and evaporate in a vacuum to get a red oil which is treated with a little portion of isopropanoi to precipitate cocaine. As you can see, this is quite a chore. The coca leaves give ecgonine, which as you can see, is only a Jump away from cocaine. If you can get egconine, then dissolve 8l/2 g of it in 100 ml of ethanol and pass (bubble) dry HC1 gas through this solution for 30 min. Let cool to room temp and let stand for another 11/2 hours. Gently reflux for 30 min and evaporate in vacuo. Basify the residue oil with NaOH and filter to get 8.4 g of methylecgonine, which is converted to cocaine as in the cocaine step above. Below is given a somewhat easier method of producing tropinone by the general methods of Willstatter, who was instrumental in the first synthetic production of cocaine and several other alkaloids. After reviewing this method, I found it to be simpler than the above in many respects. Tropinone. 10 g of pyrrolidinediethyl diacetate are heated with 10 g of cymene and 2 g of sodium powder, the reaction taking place at about 160¡. During the reaction (which is complete in about 10 min) the temp should not exceed 172¡. The resulting reaction product is dissolved in water, then saturated with potassium carbonate, and the oil, which separates, is boiled with dilute sulfuric acid. 2.9 g of tropinone picrate forms and is filtered. Here are two more formulas devised by Willstatter that produce tropinone from tropine. Take note of the yield differences. Tropinone. To a solution of 25 g tropine, dissolved in 10 times its weight of 20% sulfuric acid are added 25 g of a 4% solution of potassium permanganate in 2 or 3 g portions over 45 min while keeping the temp at 10-12¡. The addition of permanganate will cause heat (keep the temp 10-12¡) and precipitation of manganese dioxide. The reaction mixture is complete in I hour. A large excess of NaOH is added and the reaction is steam distilled until I liter of distillate has been collected. The tropinone is isolated as the dibenzal compound by mixing the distillate with 40 g of benzaldehyde in 500 cc of alcohol and 40 g of 10% sodium hydroxide solution. Let stand several days to get dibenzaltropinone as yellow needles. Yield: 15.5 g, 28%. Recrystallize from ethanol to purify. Tropinone. A solution of 12 g of chromic acid in the same amount of water (12 g) and 60 g of glacial acetic acid is added dropwise with stirring over a period of 4 hours to a solution of 25 g of tropine in 500 cc of glacial acetic acid that has been warmed to 60-70¡ and is maintained at this temp during the addition. Heat the mixture for a short time on a steam bath until all the chromic acid has disappeared, cool and make strongly alkaline with NaOH. Extract with six 500 cc portions of ether and evaporate the ether in vacuo to get an oil that crystallizes readily. Purify by converting to the picrate or fractionally distill, collecting the fraction at 224-225¡ at 714 mm vacuo. The tropinones can be used in the above formula (or in a formula that you have found elsewhere) to be converted to cocaine. Remember to recrystallize the 2-carbomethoxytropinone before converting to methylecgonine.
Preparation of Freebase Cocaine and "Crack"
I want first to express my personal opinion that freebasing is a very bad thing to do for your body and mind. I have seen a few people hooked on it, and it is not a nice thing to see. I strongly disrecommend doing it. It is easy to overdose and die of cardiac arrest. Some people doing freebase will exhibit the same kind of behavior as those rats whose pleasure centers are electrically stimulated: they will do it until either the supply runs out, or until they die.
The recipes are readily available. In fact, a few years ago, police officers would go to great lengths explaining how crack was made when given interviews (at least in Montreal)! There was also an article in Time a few years ago explaining the procedures.
I have never tried any of those procedures or smoked freebase, and will never do it. The information I post comes from a used booklet I bought a long time ago ("Cocaine Handbook", by Davis).
Crack is actually a impure form of freebase. Procedures for both substances are based on the fact that while cocaine hydrochloride is very soluble in water, base cocaine is almost insoluble.
Freebase
Baca : Sejarah sebuah nama
Mix about 1 g of coke in 10 ml of water in a small vial. Slowly add drops of ammonia to the solution. A white milky precipitate will form. Stop adding ammonia when additional drops no longer result in precipitation. Add 5 ml of ethyl ether, close vial, and shake. The precipitate (freebase) will dissolve in the ether. Siphon off the ether with a pipette (ether and water don't mix), and slowly drip it on a plate. As the ether evaporates, white crystals will form. This is the evil freebase. Crush the crystals and put under a heat lamp for at least 24 hrs to let the solvent evaporate.
ETHYL ETHER IS EXTREMELY FLAMMABLE. IN THE PRESENCE OF AIR IT CAN FORM PEROXIDES WHICH WILL SPONTANEOUSLY EXPLODE! ALSO, ETHER CAN "CRAWL" FROM AN OPEN BOTTLE AND TRIGGER AN EXPLOSION MANY FEET AWAY.
This is how Richard Pryor almost died. A lot of untrained people killed themselves doing that procedure, and this is why crack is now more popular.
Crack
Mix 2 parts ok coke HCL for 1 part baking soda in 20 ml of water. Heat solution gently until white precipitates form, and stop heating when precipitation stops. Filter and keep precipitate. wash precipitate once with water (this procedure usually omitted in street product). Dry 24 hours under heat lamp. Voila. The product is much less pure (there is lots of baking soda left) but the procedure is safer.
PCP Synthesis
Scanned from Recreational Drugs: A Complete Guide to Manufacturing
PHENCYCLIDINE HYDROCHLORIDE
Phencyclidine and Other l-Phenylcyclohexylamines. Phencyclidine (PCP or angel dust) and its analogs create many different types of effects, dependent mainly on the individual user. It was first used to immobilize primates and is still used as an analgesic and/or anesthetic agent. It has been used on humans for the same purpose with limited success. I chose to put PCP into the hallucinogens chapter instead of the analgesics chapter because of the hallucinations the drug produces.
As stated above, the effects are mainly determined by the user. Some people experience paranoia, others have fits of rage, and others have great euphoria. Mood alterations are always accompanied with time, perception and visual hallucinations. Some people have tried the drug and do not agree with it, so I do not approve of the practice of telling people that your PCP is THC or some other hallucinogen. These drugs are quite potent, so use them with a great deal of respect (I think that overdoses have CP the bad reputation that follows it today) as bummers from this drug have occurred often.
The way that ethylamine, diethylamine, methylamine, piperidine, etc., can be used as analogs of one or another reminds me of the synthesis of LSD or DMTs. The formula is quite easy to carry out and it gives good yields in large quantities. Note: Given are several different methods. You may use any way that you feel will suit your needs and you may substitute any of the amines with an equimolar amount of amine analog to produce the desired l-phenylcyclohexylamine. However, the formulas stated give the best yields obtainable with that particular amine.
These drugs are active orally, intermuscularly, and also by smoking. They should be kept in a dark, well stoppered bottle, in a freezer as much as possible. CA, 13881 (1963).
METHOD 1. A mixture of 100 g of anhydrous ethylamine and 220 g of cyclohexanone is kept 16 hours, shaken with solid KOH, and the oil layer is removed by decantation. Distill the oil layer in vacuo to get the intermediate N-cyclohexylidenethylamine. Prepare a mixture of phenyllithium by mixing 11 g of lithium and 76 ml PhBr in 500 ml of Et20. Add the phenyllithium dropwise to a solution of 51 g of the N-cyclohexylidenethylamine in 500 ml of Et20, with stirring and cooling, to keep the temp at 0¡. Stir for one hour and then decompose by adding water. Separate the Et20 layer, wash with H20 and distill to get 1- phenylcyclohexylethylamine or analog. The hydrochloride form is obtained in the usual way, as given below.
METHOD 2. A mixture of 170 g of piperidine, 220 g of cyclohexylamine, and 750 ml of benzene is azeotropically distilled until the evolution of H20 stops, then vacuum distill to get cyclohexenyl-piperidine. p-toluenesulfonic acid monohydrate (190 g) in 250 ml of PhMe is heated under a water trap until all the H20 is removed, then add a solution of 165 g of cyclohexyl-piperidine in 500 ml of Et20, with cooling, to keep temp at 0¡. A solution of I mole of PhMgBr (made from 157 g of PhBr and 24 g of Mg) in 750 ml of Et20 is added (still holding the temp at 0¡ to 5¡). The mixture is stirred for an additional 30 min after the dropwise addition is complete. Decompose the mixture by adding an excess saturated NH4Cl and NH40H. The Et20 layer is removed, dried over K2CO3, and distilled to give phenylcyclohexylpiperidine. Convert to the hydrochloride form by dissolving the free base in an excess of iso-PrOH-HC1 and then precipitate the salt (the hydrochloride) with Et20 and crystallize from Et20-iso-PrOH (this is a mixture)
